Myasthenia Gravis

Stem Cell Therapy for Myasthenia Gravis

Stem Cell Therapy for Myasthenia Gravis

Myasthenia Gravis (MG) is a neural or nervous system disorder that results in quick body fatigue and muscle weakness. Stem Cell Therapy can be a better alternative to all the other treatment options due to its non-invasiveness, flexibility, and efficacy. Stem Cell Therapy can work on the root cause of the problem with fewer side effects instead of working on the symptoms of the disease.

 

About Myasthenia Gravis (MG)

  • Myasthenia Gravis is a nervous system disease characterized by rapid fatigue and weakness of the voluntary body muscles.

    Generalized Myasthenia Gravis affects different muscle groups of the body, making it difficult to perform the movement. However, Juvenile MG is a rare type of autoimmune disorder of NMJ (neuromuscular junction). 

    This disorder results in:

    • Generalized weakness

    • Ocular manifestations

    • Onset is usually before the age of 18 years

  • The most common causes of CD are:

    • Immunity: A few species of bacteria and viruses can trigger Crohn’s disease, causing abnormal immune responses in the digestive tract.

    • Genetics: Crohn’s disease is more common among people who have a family history of the disease. Genes may play a vital role in making people more susceptible to the disease.

    • Age and gender: People in their youth (before 30 years) have more chances of developing the disease. However, the black population of the United Kingdom and North America are at the highest risk of the disease.

  • Some factors that may worsen the symptoms of MG are:

    • Overactive or underactive thyroid

    • Stress, illness, and infections

    • Fatigue and lethargy

    • Menstruation and pregnancy

    • Autoimmune conditions

    • Medications such as beta-blockers, quinine, quinidine sulfate, phenytoin, and antibiotics

  • The most common symptoms are:

    • Change in the facial expressions, smiling defects, masked face appearance

    • Weakness in the limbs can cause abnormalities in the gait of the patient

    • The dropping of eyelids (one eyelid or both) causes ptosis

    • Impairment in speaking due to speech muscles impairment

    • Weakness in legs, arms, and neck

    • Diplopia (double vision) can either be vertical or horizontal, which can be resolved when one or both eyes are closed

    • Difficulty swallowing and chewing food

    • Difficulty breathing, controlling head movement, and using arms for work

 

The Treatment Journey

  • Treatment for Myasthenia Gravis consists of main approaches:

    • Medications: Cyclosporine, cholinesterase inhibitors (Regional, Mestinon), corticosteroids (Rayos), immunosuppressants (mycophenolate mofetil, azathioprine, methotrexate, and tacrolimus

    • Surgery: Robot-assisted thymectomy and Video-assisted thymectomy

    • Intravenous therapy: Plasmapheresis, monoclonal antibody (Rituximab and eculizumab), and Intravenous immunoglobulin

  • Mesenchymal Stem Cells can induce long-term, improved, and controlled prognosis for patients suffering from myasthenia gravis who were resistant to other treatment options. In almost 10% of all the MG patients, these patients are resistant to all the other treatment options because of disturbances in the cell structures. Such patients make the best candidates for the transplantation of MSCs with Stem Cell Therapy.

  • Neurological Diseases have a high rate of fatality and incapacitation, which prevents the proper functioning of different parts of the brain. Stroke, Parkinson's disease, and Alzheimer's disease are the most common neurological disorders, which can cause severe damage to brain tissues and cells. The traditional treatment of these diseases consists of endovascular thrombectomy (ET), IV-tPA (intravenous tissue plasminogen activator), and other medications. 

    One of the modern treatment techniques for neurological disorders is the use of Exosomes along with Stem Cell Therapy. According to the research data, exosomes can improve angiogenesis, ischemic boundary zone neurogenesis, neurite remodeling, and synaptic plasticity. Many researchers claim that the conjunction of Stem Cell Therapy and Exosomes can upgrade the functional, tissue levels, and even cellular recovery in individuals with neurological diseases and damages. 

    Intravenous Mesenchymal Stem Cells, along with Exosomes administration, can help with improved white matter integrity by inducing different responses post-stroke as:

    • Oligodendrogenesis

    • Remyelination

    • Axonal sprouting

    Moreover, Exosomes also enhance the expression of microRNAs such as miR-133b, miR-210, miR-184, and miR-17-92 clusters. These microRNAs have neuroprotective properties, which aid in the good prognosis of the disease.

 

How is the treatment at The Renue Medical Centre different?

The Stem Cell Therapy (SCT) at The Renue Medical Centre is a holistic approach to treating Myasthenia Gravis (MG).

Your Renue Journey does not end after your last day of SCT. We follow up with you to assert your progress since the treatment for Myasthenia Gravis with Stem Cells consists of four phases:

  1. Pre-treatment: Clinical evaluation, lab test results, and other diagnostic procedures. You will take our Renue Epigenetic Test powered by TruDiagnostics that will assert your biological age and other important health markers. Your TruDiagnostics test is part of The Renue Difference. It provides your doctor with critical information about your health and your true age (biological vs. chronological). After the epigenetic test and we have received all your medical records, your Patient Advisor will assist you in planning your travel to Puerto Vallarta.

  2. Treatment day: The treatment starts with taking a specific amount of blood through apheresis. After taking the Stem Cells, the rest of the blood is returned to the donor.

  3. 30, 60 & 90 days post-treatment follow-up: MG symptoms clinical evaluation, flare-up frequency, and lab test results

  4. Six months post-treatment: MG symptoms clinical evaluation, flare-up frequency, lab test results, X-ray report, and review of the diagnostic criteria

 

Your Treatment Journey

 Experience The Renue Difference in Puerto Vallarta

Arrival Day

Upon arrival in Puerto Vallarta, a Renue representative will meet you at the airport in one of our special vans to transport you to the hotel. 

Our representative will quickly review your schedule for the coming days for your peace of mind. Renue makes it worry-free, so don't worry!

 Evening

  • You traveled all this way, so would you like to check our list of recommended restaurants? We can make reservations for you to enjoy the great food and warm atmosphere of Puerto Vallarta.

  • Check out the Renue chauffeur for recommendations, reservations, leisure activities, and your transportation needs.

 
 

Day 1. Enjoy The Renue Difference

A better life starts now! 

  • Count on your Renue Advisor and staff to help you have a pleasant experience. Our Renue chauffeur will pick you up from the hotel and take you to The Renue Medical Centre in the Joya Hospital. Our staff will welcome and assist you at the Centre.

    • Our staff will check you in at the Centre and take you on a tour to the facilities, including The Renue Laboratory, where your Stem Cells and Exosomes are produced. You will also visit the Hyperbaric Chamber facility, an essential part of The Renue Difference.

    • After your check-in, our medical associates will proceed with any necessary blood work or tests organized by your Patient Advisor. 

    • After that, you will meet with your doctor to review your file. Then, your doctor will make any adjustments to your treatment schedule submitted by your Renue Patient Advisor. 

    • Once your doctor has reviewed your file, additional testing might be required—for example, X-Rays, MRIs, and others. 

    • After that, you will have your first Hyperbaric Oxygen Therapy (HBOT) session.

    • Following your first treatment session, our Renue chauffeur will return you to your hotel.

    Evening

    Do you have any plans for the evening? Or maybe you would need a Renue chauffeur? 

    Remember that relaxation can improve your health, too, so feel free to ask for suggestions. They know the places to go in Puerto Vallarta.

 

Day 3 & 4. You're almost done.

The 3rd Hyperbaric Session makes a difference.

  • Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Centre. 

    • Your scheduled treatment will start as soon as you arrive. 

    • Then, after your treatment and second Hyperbaric Chamber session, your Renue chauffeur will return you to the hotel.

    Evening

    Your Renue Journey allows you to explore all that Puerto Vallarta has to offer. 

     Ask our Renue chauffeur for suggestions, and remember to enjoy yourself.

 

Day 2. Now you're a pro!

Treatment Day & Second Hyperbaric Session

  • Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Centre.

    The medical team will welcome you and start your treatment for Myasthenia Gravis as soon as you arrive: 

    • 300 Million Stem Cells IV*

    • Lyophilized Placenta Subcutaneous injection

    • 16 Billion Exosomes*

    *The actual quantity of Stem Cells depends on the patient’s body weight and the severity of the disease.

    SCT is a successful treatment for the regeneration of cells, but combining Exosomes can even enhance its efficiency. Exosomes can be 3x more concentrated with growth factors to proliferate cell production compared to adult Stem Cells.  Read more here.

    Then, after your treatment and second Hyperbaric Chamber session, your Renue chauffeur will return you to the hotel.

    Evening

    Puerto Vallarta is a beautiful place; we suggest you don't miss out and enjoy your stay. You know it: ask our Renue chauffeur for suggestions and have fun!

 

Day 5. Departure or extended stay?

It's not over yet.

  • Our Renue chauffeur will pick you up from the hotel. Then, they will take you to the airport (or another treatment) according to your schedule.

    However, maybe you would like to extend your stay and your wellness holiday! Puerto Vallarta is stunning!

    Talk to our Renue chauffeur. Our team will contact you to confirm all details: tours, restaurants, and other treatments you would like to have.

 
 

Are you going to miss us? 

Don't forget our follow-up treatments. Talk to your Patient Advisor:

Post-treatment:

  • 30, 60 & 90 days follow-up: MG symptoms to check for flare-up frequency, improvements, pain, and irritation.

  • Six months after treatment: MG symptoms clinical evaluation, lab tests, flare-up frequency, quality of life, and disease prognosis.

 

 Significance of Hyperbaric Chambers post-treatment:

Hyperbaric Chambers are oxygen-rich chambers. Three sessions are given to the patient after the treatment to:

  • Reduce the levels of different antibodies like IgM and IgA, yielding an immunosuppressive effect on the body

  • Cause positive effects of oxygen therapy in treating inflammation 

  • Cause up-regulation of several beneficial growth factors 

  • Down-regulation of pro-inflammatory cytokines

  • Mobilization of the already administered stem cells in the body to proliferate the further growth of the stem cells

  • Lessen the need for drug therapy in combination with the stem cell therapy

  • Combat the excess concentrations of ROS by increasing the levels of GP x (glutathione peroxidase), SOD (superoxide dismutase), and CAT (catalase)

 

Expected Results

SCT to live a better life: Benefits and outcomes

The effectiveness of Stem Cell Treatment can improve all your symptoms, causing a considerable impact on your quality of life and daily activities.

As part of The Renue Difference, you will receive three Hyperbaric Chamber sessions that greatly improve SCT efficacy and stimulate the body cells to combat Myasthenia Gravis. These sessions comprise three days: one day before treatment, after treatment, and on the day of treatment.

According to results, clinical outcomes, and pre-and post-treatment observations, SCT has been shown to help

  • Reduce Myasthenia Gravis progression

  • Speed up tissue repair

  • Regrow and repair tissues after six months

After the SCT procedure, an MRI test depicts the further need for the treatment at a specific body site.

Talk to our Patient Advisor to learn more about SCT at The Renue Centre.


Expected results and prognosis:

Increased independence, stable posture, decreased neuro damage progression, improved balance and coordination, and life satisfaction

 

FAQ’s

  • The most common and mild side-effects of Stem Cell Therapy for MG are:

    • Painful injection area /site

    • Allergic reactions

    • Fever

    • Lethargy and fatigue

    • Bleeding from the site of injection

  • Fever, lethargy, and pain are managed through the appropriate drugs along with the treatment. Pre-treatment education can help with awareness of slight side effects of the therapy. Bleeding and swelling of the injured site are manageable via proper technique. Allergic reactions are preventable through pre-injection history and care.

 

Stem Cell Therapy is a new and promising method of treating Myasthenia Gravis. It has the potential to be more effective than previous methods and also carries less risk. At present, Stem Cell Technology is still in the developmental stage, but rapid developments and advances indicate its potential uses in direct treatments of Myasthenia Gravis.

The benefits and effects of Stem Cell Therapy depend on several factors: the patient's health condition, underlying issues, lifestyle, and others.

To assess your expected results, we would like to know more about you. 

A medical advisor will talk to you about your diagnosis and treatment options and collect information for the attending physician; they can answer all your initial questions:

  • Will the therapy work for my case? 

  • What does the treatment involve? Is it painful?

  • Is it expensive? How much does it cost?

 

Start your Wellness Journey!

Click on the button below to book a consultation to answer your questions and discuss your medical history, your treatment journey, and your goals.