Systemic Lupus Erythematosus (SLE) is an autoimmune condition that affects the major body organs resulting in a high mortality rate. The treatment options for SLE are very limited. Stem Cell Therapy can be the best available treatment option in new times due to its innovation and novelty.

Systemic Lupus Erythematosus is an autoimmune disease that occurs as a result of immune system attacks and infections. SLE is the most common cause of lupus which causes damage to organs and tissues, joints, skin, kidneys, brain, lungs, and vasculature of the body. Until now, there hasn’t been any absolute treatment for SLE.

The exact cause of lupus is not fully understood, but it is believed to result from a combination of genetic, environmental, hormonal, and immune system factors. Here are the primary contributors:

1. Genetic Factors

·       Family history: Lupus tends to run in families, suggesting a genetic predisposition. Certain genes are associated with a higher risk of developing lupus, but having these genes alone does not mean someone will definitely develop the disease.

·       Gene mutations: Mutations in genes that regulate immune system function can lead to abnormal immune responses, increasing the likelihood of developing autoimmune diseases like lupus.

2. Environmental Triggers

·       Sunlight (UV Radiation): Exposure to ultraviolet (UV) light can trigger lupus flares or onset in individuals predisposed to the condition, leading to skin rashes and other symptoms.

·       Infections: Certain viral or bacterial infections, such as Epstein-Barr virus (EBV), have been suggested to play a role in triggering lupus in genetically susceptible individuals.

·       Medications: Some drugs can induce lupus-like symptoms, a condition known as drug-induced lupus. These symptoms typically resolve once the medication is stopped.

·       Toxins and chemicals: Exposure to environmental toxins, such as cigarette smoke or silica dust, may also contribute to lupus development or exacerbation.

3. Hormonal Factors

·       Estrogen: Lupus is more common in women, particularly during their reproductive years, suggesting that hormones like estrogen may play a role. Higher estrogen levels can stimulate the immune system, which may increase the risk of autoimmune diseases.

·       Hormonal fluctuations: Pregnancy, menstruation, and hormone therapy can all affect lupus activity, leading to symptom flares in some women.

4. Immune System Dysfunction

·       In lupus, the immune system becomes hyperactive and loses its ability to distinguish between the body’s own tissues and foreign invaders, such as bacteria or viruses. This leads to the production of autoantibodies, which attack healthy tissues, causing widespread inflammation and damage to organs like the skin, kidneys, heart, and joints.

5. Other Risk Factors

·       Gender: Lupus predominantly affects women, with around 90% of cases occurring in females.

·       Age: While lupus can develop at any age, it most commonly occurs in individuals between the ages of 15 and 45.

·       Ethnicity: Lupus is more prevalent in certain ethnic groups, including African Americans, Hispanics, Asians, and Native Americans.

6. Stress and Immune Response

·       Physical or emotional stress can exacerbate lupus symptoms by influencing immune system activity. Stress can lead to increased inflammation, triggering lupus flares in individuals who are already predisposed to the disease.

In summary, lupus is caused by a complex interaction of genetic predisposition, environmental exposures, hormonal influences, and immune system dysfunction. These factors work together to trigger the onset and progression of the disease in susceptible individuals.

Several factors can increase the risk of developing systemic lupus erythematosus (SLE). These include:

1.    Ethnicity and Race

o   While lupus can affect people of any race, it is more prevalent in certain ethnic groups. African Americans, Hispanics, Asians, and Native Americans are at higher risk of developing SLE compared to the Caucasian population. The disease also tends to be more severe in these groups, with higher rates of kidney involvement and complications.

2.    Family History

o   A family history of lupus or other autoimmune diseases increases the likelihood of developing SLE. Although no single gene causes lupus, certain genetic variations may make individuals more susceptible to the condition.

3.    Sex

o   Women are significantly more likely to develop lupus than men, accounting for around 90% of all SLE cases. The hormonal differences, particularly related to estrogen, are thought to contribute to the higher prevalence in women.

4.    Age

o   While lupus can occur at any age, the most common age of onset is between 15 and 44 years, particularly during the reproductive years. This period coincides with hormonal changes that may influence immune function.

Lupus symptoms can vary a lot from person to person, and the condition can mimic other diseases, making it hard to diagnose. Here are the common symptoms of systemic lupus erythematosus (SLE):

1.    General Symptoms

o   Fatigue: Extreme tiredness, which is one of the most common and exhausting symptoms.

o   Fever: Low-grade fevers without any obvious cause, which may signal inflammation.

o   Weight Changes: Unexplained weight loss or gain.

2.    Musculoskeletal Symptoms

o   Joint Pain and Swelling: Lupus often affects the joints, especially in the hands, wrists, and knees, causing pain, swelling, and stiffness, which are often worse in the morning.

o   Muscle Pain: Muscle aches and weakness may also occur.

3.    Skin and Hair Symptoms

o   Butterfly-Shaped Rash: A rash across the cheeks and nose, usually triggered by sun exposure, is a classic sign of lupus.

o   Photosensitivity: Sensitivity to sunlight can cause rashes and other skin issues.

o   Discoid Rash: Raised, scaly patches, often on the face, neck, or scalp.

o   Hair Loss: Thinning hair or patches of hair loss (alopecia), especially during lupus flares.

4.    Cardiopulmonary Symptoms

o   Chest Pain: Inflammation around the heart (pericarditis) or lungs (pleuritis) can cause sharp chest pain that gets worse when breathing.

o   Shortness of Breath: Lung inflammation can lead to breathing difficulties or lung infections.

5.    Kidney Symptoms (Lupus Nephritis)

o   Swelling: Kidney inflammation can cause fluid retention, leading to swelling in the legs, feet, or around the eyes.

o   Blood in Urine: The presence of protein or blood in urine may indicate kidney involvement.

6.    Neurological Symptoms

o   Headaches: Persistent headaches, often similar to migraines.

o   Memory and Concentration Issues: "Lupus fog" can cause memory problems or difficulty focusing.

o   Seizures and Strokes: In severe cases, lupus can affect the brain, leading to seizures or strokes.

7.    Gastrointestinal Symptoms

o   Abdominal Pain: Inflammation in the digestive system can cause pain, nausea, or vomiting.

o   Mouth or Nose Ulcers: Painful sores in the mouth or nose are common during lupus flares.

8.    Blood and Circulatory Symptoms

o   Anemia: Low red blood cell count can cause fatigue, weakness, and pale skin.

o   Blood Clots: Lupus increases the risk of blood clots.

o   Low White Blood Cells or Platelets: This increases the risk of infections or bleeding.

9.    Raynaud's Phenomenon

o   Some people with lupus experience fingers and toes turning white or blue in response to cold or stress.

Lupus symptoms can be mild or severe, and they can come and go, with periods of flares and remission. Because lupus can resemble other conditions, it’s often called "the great imitator." If you experience any of these symptoms, it’s important to seek medical advice for early detection and treatment to help manage the disease and prevent complications.

Lupus treatment usually combines medications and lifestyle changes to help control symptoms, prevent flare-ups, and reduce organ damage. The treatment plan is customized to each person, depending on the severity of their symptoms and which organs are affected. Below are the most common approaches:

1. Medications

1.1. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Medications like ibuprofen and naproxen are often used to reduce pain, swelling, and inflammation, especially for mild lupus affecting joints and muscles.

1.2. Antimalarial Drugs

Hydroxychloroquine (Plaquenil), originally used to treat malaria, is key for managing lupus. It helps reduce inflammation, prevent flares, and protect organs like the kidneys and brain from damage.

1.3. Corticosteroids

Drugs like prednisone are powerful anti-inflammatories used to control severe lupus symptoms. However, they are usually prescribed for short-term use due to side effects like weight gain, high blood pressure, and bone thinning.

1.4. Immunosuppressants

For moderate to severe lupus, immunosuppressants help stop the immune system from attacking healthy tissues. Common options include:

·       Azathioprine (Imuran)

·       Mycophenolate mofetil (CellCept)

·       Methotrexate

·       Cyclophosphamide (Cytoxan), especially for serious kidney involvement.

1.5. Biologic Therapies

Newer drugs like belimumab (Benlysta) and rituximab (Rituxan) target specific parts of the immune system to reduce lupus activity. These are used when other treatments don’t work well enough.

2. Lifestyle Changes and Self-Care

2.1. Sun Protection

UV light can trigger lupus flares, so it’s important to avoid direct sunlight, wear sunscreen with a high SPF, and use protective clothing and hats when outdoors.

2.2. Healthy Diet

A balanced diet full of fruits, vegetables, whole grains, and lean proteins can help reduce inflammation. Limiting salt is important, especially if taking corticosteroids, as they can cause fluid retention and high blood pressure.

2.3. Exercise

Regular, moderate exercise helps keep joints flexible, strengthens muscles, and improves heart health. It also helps manage stress, which can trigger lupus flares.

2.4. Stress Management

Managing stress is key to avoiding lupus flares. Techniques like meditation, yoga, and deep-breathing exercises can help reduce stress and improve overall well-being.

2.5. Adequate Rest

Fatigue is common in lupus, so getting enough rest is important to help the body recover and avoid overexertion.

3. Treatments for Specific Organs

If lupus affects specific organs, additional treatments may be needed. For example:

·       ACE inhibitors or angiotensin II receptor blockers (ARBs) can help protect the kidneys.

·       Anticoagulants may be prescribed to prevent blood clots in people with lupus-related clotting issues.

4. Regular Monitoring

Regular check-ups with a healthcare provider are essential to track disease activity, adjust medications, and detect complications early. Blood and urine tests, along with imaging studies, are part of routine monitoring for lupus patients.

Lupus treatment is personalized to each person’s needs and focuses on reducing inflammation, managing symptoms, preventing flares, and protecting the body from damage. A mix of medications, lifestyle changes, and regular medical check-ups helps control the disease and improve quality of life.

Stem cell therapy utilizes the body's natural repair mechanism to promote healing and regeneration. Stem cells, which are found in fat cells, bone marrow, and donor cord blood, have the unique ability to activate the growth of new, healthy cells in damaged tissues. In this therapy, mesenchymal stem cells (MSCs) from donor cord blood are applied to the affected area, encouraging the body’s repair processes.

By enhancing the body’s ability to regenerate tissue, stem cell therapy boosts the natural healing mechanisms, facilitating recovery and introducing new, healthy stem cells to the site of damage.

At Renue we believe that if you are truly interested in Healthspan (Living better, not just longer.”) then it’s important that we are aware of our Biological Age vs Chronological Age.  Remember you can”t measure success without a starting point.  With TruDiagnostic’s TruAge testy you will receive 9 personalized Epigenetic Health Scores and actionable insights to slow aging

Biological Age

How old your body is compared to your real age

Pace of Aging

How quickly you're aging each year

Organ System Ages

The age of key organs (heart, brain, liver, etc.)

Fitness Age

Your physical health based on strength, lung capacity, and movement

Smoking Impact

How smoking has affected your epigenetic age

Alcohol Impact

How alcohol consumption has influenced your health

Stem Cell Therapy has the potential to cure degenerative disorders and injured tissue repair. Despite the therapeutic promise of Stem Cell Treatments, there are still hazards that have yet to be identified as:

·       Status of cell differentiation 

·       Proliferation capacity of Stem Cells

·       Location and route of administration

·       Long-term survival of injected Stem Cells

·       In the event of irreparable tissue loss, the potential for simultaneous tissue regeneration

The risks connected with Stem Cell Treatment are presently minimal and uncommon. When patients exhibit adverse effects, cautious care is usually recommended. Over-the-counter drugs can help reduce negative effects in cases of infections and inflammation. Pre-operative care and patient records are very important in controlling and reducing risk factors.