ULCERATIVE COLITIS

Stem Cell Therapy for Ulcerative Colitis

Stem Cell Therapy for Ulcerative Colitis

What is Ulcerative Colitis?

Ulcerative Colitis (UC) is painful sores or wounds which are slow to heal and cause irritation of the affected body part. Ulcerative Colitis are the skin and viscera common issues, which may show symptoms according to the affected area. Ulcerative Colitis can range from the skin’s outer layer to the internal linings of significant organs such as the stomach. Some of them are resolvable spontaneously, while others require careful medical treatment to prevent further complications.

The most prevalent types of Ulcerative Colitis are:

  • Genital Ulcerative Colitis

  • Peptic Ulcerative Colitis (gastric Ulcerative Colitis, esophageal Ulcerative Colitis, duodenal Ulcerative Colitis)

  • Mouth Ulcerative Colitis

  • Arterial Ulcerative Colitis

  • Venous ulcer

  • Diabetic foot Ulcerative Colitis

What causes Ulcerative Colitis?

Just like the symptoms of the different Ulcerative Colitis, there are different causes for the different types of them. Most stomach Ulcerative Colitis or Peptic Ulcerative Colitis occurs due to the infection from Pylori (helicobacter pylori) bacteria. However, chronic use of NSAIDs can also cause severe damage to the stomach lining, leading to stomach Ulcerative Colitis.

Diabetic foot ulcer occurs due to diabetic neuropathy, incomplete wound healing, or gangrene (in severe cases). Diabetic foot Ulcerative Colitis can even lead to amputation of the affected part in extreme cases. Similarly, mouth and genital Ulcerative Colitis occur as a result of bacterial and fungal infections. A syndrome known as Zollinger-Ellison syndrome can cause intestinal and stomach Ulcerative Colitis by enhancing the acid production in the body. Of all the peptic Ulcerative Colitis, this syndrome accounts for less than one percent of cases because it is rare.

What are the symptoms of Ulcerative Colitis?

The symptoms of Ulcerative Colitis depend upon the area involved. For instance, in the case of peptic Ulcerative Colitis, you might experience:

  • Bloating and heartburn

  • Nausea and vomiting

  • Chest pain, belching, and unexplained weight loss

In the case of arterial Ulcerative Colitis, you might experience:

  • Hairless skin with no bleeding

  • Black, yellow, and red sores

  • Leg pain and less circulation, leading to cooler temperatures in the affected area

Venous Ulcerative Colitis might show scabbing, itchy skin, swelling, inflammation, and discharge from the affected area. Similarly, mouth ulcer may be indicative of:

  • Hormonal changes and vitamin deficiencies

  • Bacterial and fungal infections

  • Food allergies and other diseases

THE TREATMENT JOURNEY

How is Ulcerative Colitis treated?

The treatment of Ulcerative Colitis also depends upon the area involved. Stomach Ulcerative Colitis usually requires oral medications and eating precautions. H2 receptor blocker medications can work the best for ulcer prevention. Antacids, a healthy lifestyle, a healthy diet, probiotic food, antioxidants, and honey can help with relieving the symptoms of Ulcerative Colitis in the body. However, there is always a need for an absolute cure for a disease to prevent its remittance in the future.

How can Stem Cell Therapy treat Ulcerative Colitis?

Stem Cell Therapy for UC is carried out with the 300 million Stem Cells administered through the IV route. SCT for UCs is more effective because it offers treatment without any potential side effects to the body.

MSCs (Mesenchymal Stem Cells) are the most suitable alternative for the treatment of Ulcerative Colitis in comparison to other Stem Cells options. MSCs help in targeting the immune system and release cytokines as signaling proteins. Cytokines bring the immune system back into order to work according to its function. 

Because of their immune-suppressive and regenerative qualities, MSCs can be considered a bio drug for IBD treatment. MSCs outperform the other often employed adult Stem Cells, Hematopoietic Stem Cells, in terms of reduced side effects and improved tolerance.

Interleukin-35 (IL-35) is an immunosuppressive cytokine recently found as a potential treatment for chronic inflammatory and autoimmune illnesses. The progression of Ulcerative Colitis can be delayed, reverted, or even stopped entirely with Stem Cell therapy. The treatment's success rate is proportional to the patient's age, the duration of the ailment, and the patient's state.

For patients who have Ulcerative Colitis, Stem Cells Therapy can help with:

  • Enhanced healing of the patients

  • Slow disease progression and strengthening of the defense system

  • A suppressed mucosal immune response due to expression of interleukin 35 by mesenchymal Stem Cells due to their immunoregulatory and hypoimmunogenic properties

  • More immediate healing or prognosis time of six months in comparison to years

  • No side effects and complications of the procedure

Exosomes and Autoimmune diseases:

According to the clinical literature, Exosomes combined with MSCs help in autoimmune diseases by regulating the inflammatory cytokines, microenvironment, and immune cells. These processes have a potent relation with both adaptive and innate immune cells. In these cells, macrophages, Treg cells, Th17, immunoregulatory miRNAs, and CD4+Th1 are the most crucial ones. 

Exosomes-combined-MSCs help in the regulation of T-Cell subsets in cases of autoimmune diseases. Moreover, the MSCs-Exosomes also aid in reducing the levels and concentration of pro-inflammatory Th17 and TH1 cytokines as IL-17AF, IL-12p70, and IL-6. However, the same MSCs-Exosomes help in increasing the concentration of anti-inflammatory Treg. 

Therefore, MSCs-Exosomes increase the concentration of Treg cells and the related products without changing the concentration index of the lymphocytes to maintain immunoregulation in the body. Similar effects of these cells are seen in the cases of RA (rheumatoid arthritis) and GVHD (graft-versus-host disease). MSCs-Exosomes help improve the GVHD by suppressing the differentiation of populations of the naïve T-cells. Macrophages constitute a crucial and major portion of the innate immunity of the human body, which can be regulated through the administration of MSCs-Exosomes. According to the different microenvironments, Mo (naïve macrophages) can be polarized into anti-inflammatory (M2) or pro-inflammatory (M1) to play different roles in different conditions. Along with the autoimmune conditions, this combination therapy can also help facilitate metabolic hemostasis to attenuate obesity and adipose inflammation. Moreover, MSCs-Exosomes can also promote the M1-M2 macrophage conversion to reduce the pro-inflammatory factors or effects of the macrophage M1.

How is the treatment at The Renue Medical Centre different?

The Stem Cell Therapy (SCT) at The Renue Centre is a holistic approach to treating Ulcerative Colitis. 

Your Treatment Journey for Ulcerative Colitis with stem cells consists of four phases:

  • Pre-treatment: Physical exam, clinical evaluation, lab test results, and other diagnostic procedures.

    • You will take our TruDiagnostics epigenetics test that will assert your biological age and other important health markers. Your TruDiagnostics test is part of The Renue Difference. It provides your doctor with critical information about your health and your true age (biological vs. chronological).

    • After the epigenetic test and we have received all your medical records, your Patient Advisor will assist you in planning your travel to Puerto Vallarta.

Treatment day: Treatment days start with the initial check-up of the patient’s current health situation, vitals, and other significant tests. The route of administration of stem cell therapy for Ulcerative Colitis can be intra-arterial, intranasal, and intravenous. The dosage of the stem cells also depends upon the severity and type of the disease, which is customizable.

  • 30, 60 & 90 days post-treatment follow-up: To check for flare-up frequency, improvements, pain, and irritation

  • Six months post-treatment: Lab tests, flare-up frequency, clinical evaluation, mobility, quality of life, and disease prognosis

TREATMENT JOURNEY

Experience The Renue Difference in Puerto Vallarta 

Arrival Day

Upon arrival in Puerto Vallarta, a Renue representative will meet you at the airport in one of our Mercedes vans to transport you to the hotel. 

Our representative will quickly review your schedule for the coming days for your peace of mind. Renue makes it worry-free, so don't worry!

Evening

  • You traveled all this way, so would you like to check our list of recommended restaurants? We can make reservations for you to enjoy the great food and warm atmosphere of Puerto Vallarta. 

  • Check out the Renue chauffeur for recommendations, reservations, leisure activities, and your transportation needs.

A better life starts now! 

Day 1. Enjoy The Renue Difference.

Count on your Renue Advisor and staff to help you have a pleasant experience. Our Renuechauffeur will pick you up from the hotel and take you to The Renue Medical Centre in the Joya Hospital. Our staff will welcome and assist you at the Centre.

 

  • Our staff will check you in at the Centre and take you on a tour of the facilities, including The Renue Laboratory, where your stem cells and exosomes are produced. You will also visit the Hyperbaric Chamber facility, an essential part of The Renue Difference.

  • After your check-in, our medical associates will proceed with any necessary blood work or tests organized by your Patient Advisor. 

  • After that, you will meet with your doctor to review your file. Then, your doctor will make any adjustments to your treatment schedule submitted by your Renue Patient Advisor. 

  • Once your doctor has reviewed your file, additional testing might be required—for example, X-Rays, MRIs, and others. 

  • After that, you will have your first Hyperbaric Oxygen Therapy (HBOT) session.

  • Following your first treatment session, our Renue chauffeur will return you to your hotel.

 
Evening

Do you have any plans for the evening? Or maybe you would need a chauffeur? 

Remember that relaxation can improve your health, too. Ask our Renue chauffeur for suggestions. They know the places to go in Puerto Vallarta.

Treatment Day & Second Hyperbaric Session

Day 2. Now you're a pro!

Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Centre.

  • The medical team will welcome you and start your treatment for Ulcerative Colitis as soon as you arrive: 

  • 300 Million Stem Cells*

  • 16 Billion Exosomes*

*The actual quantity depends on the patient’s body weight and severity of the disease.

  • Then, after your treatment and second Hyperbaric Chamber session, the Renue chauffeur will return you to the hotel.

Evening

Puerto Vallarta is a beautiful place; we suggest you don't miss out and enjoy your stay. You know it: ask our Renue chauffeur for suggestions and have fun!

The third and fourth Hyperbaric Session makes a difference!

Day 3 and 4. You're almost done.

Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Centre. 

  • Your scheduled treatment will start as soon as you arrive. 

  • Then, after your treatment and third and fourth Hyperbaric Chamber session, the Renue chauffeur will return you to the hotel.

Evening

Your Renue Journey allows you to explore all that Puerto Vallarta has to offer. 

Ask our Renue Concierge for suggestions, and remember to enjoy yourself.

It's not over yet.

Day 5. Departure or extended stay? 

  • Our Renue chauffeur will pick you up from the hotel. Then, they will take you to the airport or another treatment according to your schedule. 

  • However, maybe you would like to extend your stay and your wellness holiday because Puerto Vallarta is stunning! 

  • Talk to our Renue chauffeur. Our team will contact you to confirm all details: tours, restaurants, and other treatments you would like to have.

 

Are you going to miss us? 

Don't forget our follow-up treatments. Talk to your Patient Advisor:

  • 30, 60 & 90 days follow-up: Ulcerative Colitis symptoms clinical evaluation, flare-up frequency, and lab test results.

  • Six months post-treatment: Ulcerative Colitis symptoms clinical evaluation, flare-up frequency, lab test results, X-ray report, and review of the diagnostic criteria from the American College of Rheumatology.

Significance of Hyperbaric Chambers post-treatment:

Three sessions of Hyperbaric Chambers are given to the patients after the treatment to:

  • Completely heal the fistulas or Ulcerative Colitis, which is defined as the absence of active draining and closure of the external orifices

  • Completely heal the wounds and granulation of the skin

  • Complete epithelialization of the wounded or damaged skin

  • Less need for invasive and surgical procedures for wounds restoration

  • Mobilize the stem cells recently administered inside the body

  • Reduce the events of inflammation. Inflammatory lesions and swelling associated with Ulcerative Colitis exacerbation, alleviation of the painful symptoms, and improvement of life quality in patients

  • Lessen the need for drug therapy in combination with the Stem Cell Therapy

EXPECTED RESULTS 

SCT to live a better life: Benefits and outcomes

The effectiveness of Stem Cell Treatment can improve all your symptoms, causing a considerable impact on your quality of life and daily activities.

As part of The Renue Difference, you will receive three Hyperbaric Chamber sessions that greatly improve SCT efficacy and stimulate the body cells to combat Ulcerative Colitis. These sessions comprise four days: one day before treatment, two after treatment, and on the day of treatment.

According to results, clinical outcomes, and pre- and post-treatment observations, SCT has been shown to help

  • Reduce MS progression

  • Speed up tissue repair

  • Regrow and repair tissues after six months

After the SCT procedure, an MRI test depicts the further need for the treatment at a specific body site.

Talk to our Patient Advisor to learn more about SCT at The Renue Centre.

Expected results and prognosis:

  • Expected result 1:  Immediate control of associated symptoms of Ulcerative Colitis post-treatment.

  • Expected result 2: A significant decrease in the size and number of Ulcerative Colitis, which aids in preventing the chances of amputation (as in diabetic Ulcerative Colitis), higher rates of wounds closing, healing, and epithelialization of the skin surface covering the wound.

  • Expected result 3: The enhanced quality of life and more life satisfaction.

FREQUENT QUESTIONS

What are the risk factors of Stem Cell Therapy for Ulcerative Colitis?

Treatments of Ulcerative Colitis can cause high-risk complications and side effects. Stem Cell Therapy is the most dependable procedure for Ulcerative Colitis disease now. Generally, Stem Cell Therapy has a satisfactory safety profile, good prognosis, and effectiveness. 

However, no medical procedure is 100% safe; so, the most frequent or common risk factors of SCT can be:

  • Fever

  • Allergic reactions

  • Bleeding from the site of injection

  • Painful injection area /site

  • Lethargy and fatigue

Management of Risks

Pre-treatment education can help with awareness of slight side effects of the therapy. Allergic reactions are preventable through pre-injection history and care. Bleeding and swelling of the injured site are manageable via proper technique. Fever, lethargy, and pain are managed through the appropriate drugs along with the treatment. In the case of stomach Ulcerative Colitis, damage to the mucosal lining is preventable through SCT, which doesn’t require too many medications to damage the stomach lining.

Stem Cells Therapy (SCT) has a great potential to be more effective for treating Ulcerative Colitis than previous methods and carries less risk. SCT has a great potential to emerge as one solution to all the human body problems, but it will need some time and patience.  

All the treatment options for Ulcerative Colitis have been temporary options for just treating the symptoms. With the invention of Stem Cells Replacement Therapy, hopes and prognosis of the disease treatment have been raised. It has the potential to be more effective than previous methods and also carries less risk. 

The benefits and effects of Stem Cell Therapy depend on several factors: the patient's health condition, underlying issues, lifestyle, and others. To assess your expected results, we would like to know more about you. A medical advisor will talk to you about your diagnosis and treatment options and collect information for the attending physician; they can answer all your initial questions:

  • Will the therapy work for my case? 

  • What does the treatment involve? Is it painful?

  • Is it expensive? How much does it cost?

Start your Wellness Journey!

Click on the button below to book a consultation to answer your questions and discuss your medical history, your treatment journey, and your goals.