Hashimoto's Thyroiditis
Stem Cell Therapy for Hashimoto's Thyroiditis
Stem Cell Therapy for Hashimoto's Thyroiditis
Hashimoto's Thyroiditis (HT) is the disease of the thyroid gland, which plays a significant role in the body's metabolism by releasing the thyroxine hormone. Ineffectiveness of the proper functioning of the thyroid causes HT, which is permanently curable via the replacement of damaged thyroid cells through stem cell therapy. Stem cell therapy has a great potential to be more effective than previous methods and also carries less risk. At the present time, SCT or technology is in the beginning stages. However, STC still requires careful observation and re-regulations of ethical concerns regarding its application in medical treatment.
What is Hashimoto's Thyroiditis?
HT is an autoimmune disease which attacks the body’s immune system. In patients with HT, the immune system tends to attack the thyroid, which can lead to hypothyroidism. The thyroid gland is the small gland that lies at the base of the neck or Adam’s apple, which is a vital part of the endocrine system. The endocrine gland produces vital hormones to coordinate the different functions of the body. Inflammation in Hashimoto's thyroiditis or chronic lymphocytic thyroiditis leads to under activity of the thyroid gland. The most prevalent cause of hypothyroidism is Hashimoto's thyroiditis.
What causes Hashimoto’s Thyroiditis?
The exact causes or reasons for HT are still unknown (idiopathic). However, several other factors contribute to the cause of HT, such as:
Genetics: People having a family history of this disease often transmit the symptoms to later generations. Just like other auto-immune diseases, HT also has an effect on genetics for its transmission from one generation to the other.
Gender and hormones: The prevalence of Hashimoto’s Thyroiditis is seven-time more in females than males. The reason for this incidence is the contribution of sex hormones to the disease. Some women suffer from thyroid issues during the first year post-pregnancy, but some can develop this problem in later years of life.
Excessive iodine consumption: According to researchers, specific drugs and medications consist of too much quantity of iodine. An excessive amount of iodine can trigger the susceptibility of HT in the patients.
Exposure to radiation: In addition to other causes or risk factors, excessive exposure to radiation can also cause thyroid issues. People who live nearby the atomic bomb radiations of Japan have shown a large number of cases of HT along with the type of blood cancer as Hodgkin’s disease.
Symptoms of Hashimoto's Thyroiditis:
In the initial stages, the symptoms of HT might not be too visible. However, with time, you may notice signs of swelling in the front of the throat, causing goiter. Typically, HT tends to progress slowly over the years, leading to thyroid damage and a significant decrease in thyroid hormone concentrations in the blood.
The most common signs and symptoms of HT are:
Sluggishness, fatigue, and lethargy
Constipation, dry skin, and paleness
Brittleness of nails and hair loss
Puffiness of face
Enlargement in the size of the tongue
Stiffness and pain in the body joints
Stiffness, tenderness, and pain in body muscles
Unexplained or sudden gain in body weight
Symptoms of depression and memory lapses
Prolonged or excessive menstrual bleeding
Weakness of muscles and more sensitivity to the cold
THE TREATMENT JOURNEY
How is Hashimoto’s Thyroiditis treated?
Generally, there isn’t any effective treatment to cure HT for good. However, hormone replacement therapy and medications can help me regulate the levels of hormones to restore the body's normal metabolism. The medications for the disease are available in different potencies and forms. The prescription of the medicines depends upon different factors like severity of disease, age, weight, and drug interaction with other medicines.
Synthetic hormones such as synthetic levothyroxine are hormones which functions similarly to thyroxine. The oral medications of this hormone can help in restoring the natural levels of hormones and reverse the severe symptoms of hypothyroidism. Other hormones and supplements can also help in treating the symptoms of HT.
How can Stem Cell Therapy treat Hashimoto's Thyroiditis?
According to innovative research, MSCs (Mesenchymal Stem Cells) can effectively control several inflammatory diseases like rheumatoid arthritis, experimental autoimmune disease, and myocarditis. Due to the potent immunosuppressive and regenerative properties of MSCs, these cells have become the preferable choice for regenerative medicine and different immunotherapies.
Bone marrow is the universal source of MSCs for causing a potent suppressive response to the proliferation of T-cells. However, an invasive procedure required to get these cells may cause complication risks and age-related decline in the self-renewal of these cells. Therefore, alternative sources for MSCs are adipose tissue-derived, placenta-derived, and cord-blood-derived MSCs. These sources are easy to proceed with, available in plenty of quantities, and free from concerning ethical issues.
In Hashimoto’s Thyroiditis is the destruction or damage of thyroid parenchyma, which is mostly due to:
Auto-antibodies production
Infiltration of cytotoxic T cells
Fas induction on the thyrocytes (cytokine-mediated induction)
Through in vitro studies, we know that stem cell therapy can treat the complex HT disease, which is idiopathic and is treatable with only symptomatic therapy. Limbic stem cells can help immunize PBMCs (peripheral blood mononuclear cells) through different mechanisms.
Exosomes and Autoimmune diseases:
According to the clinical literature, Exosomes combined with MSCs help in autoimmune diseases by regulating the inflammatory cytokines, microenvironment, and immune cells. These processes have a potent relation with both adaptive and innate immune cells. In these cells, macrophages, Treg cells, Th17, immunoregulatory miRNAs, and CD4+Th1 are the most crucial ones.
Exosomes-combined-MSCs help in the regulation of T-Cell subsets in cases of autoimmune diseases. Moreover, the MSCs-Exosomes also aid in reducing the levels and concentration of pro-inflammatory Th17 and TH1 cytokines as IL-17AF, IL-12p70, and IL-6. However, the same MSCs-Exosomes help in increasing the concentration of anti-inflammatory Treg.
Therefore, MSCs-Exosomes increase the concentration of Treg cells and the related products without changing the concentration index of the lymphocytes to maintain immunoregulation in the body. Similar effects of these cells are seen in the cases of RA (rheumatoid arthritis) and GVHD (graft-versus-host disease). MSCs-Exosomes help improve the GVHD by suppressing the differentiation of populations of the naïve T-cells. Macrophages constitute a crucial and major portion of the innate immunity of the human body, which can be regulated through the administration of MSCs-Exosomes. According to the different microenvironments, Mo (naïve macrophages) can be polarized into anti-inflammatory (M2) or pro-inflammatory (M1) to play different roles in different conditions. Along with the autoimmune conditions, this combination therapy can also help facilitate metabolic hemostasis to attenuate obesity and adipose inflammation. Moreover, MSCs-Exosomes can also promote the M1-M2 macrophage conversion to reduce the pro-inflammatory factors or effects of the macrophage M1.
How is the treatment at The Renue Medical Centre different?
The Stem Cell Therapy (SCT) at The Renue Centre is a holistic approach to treating HT.
Your Renue Journey does not end after your last day of SCT. We follow up with you to assert your progress, following four phases:
The treatment of Hashimoto’s Thyroiditis with Stem Cells consists of four phases:
Pre-treatment: Clinical evaluation, lab test results, and other diagnostic procedures.
You will take our Renue Epigenetic Test powered by TruDiagnostics that will assert your biological age and other important health markers. Your TruDiagnostics test is part of The Renue Difference. It provides your doctor with critical information about your health and your true age (biological vs. chronological).
After the epigenetic test and we have received all your medical records, your Patient Advisor will assist you in planning your travel to Puerto Vallarta.Treatment day: The route of administration of Stem Cells can be intra-arterial, intranasal, and intravenous. Stem Cells transplantation can range from 1 x 106 – 8 x 106 cells. The dosage of the stem cells also depends upon the severity and type of the disease, which is customizable.
30, 60 & 90 days follow-up: To check for flare-up frequency, improvements, contracture release, and spasticity
Six months after treatment: Lab tests, flare-up frequency, clinical evaluation, quality of life, and disease prognosi
YOUR TREATMENT JOURNEY
Experience Renue in Puerto Vallarta
Arrival Day
Upon arrival in Puerto Vallarta, a Renue representative will meet you at the airport in one of our Mercedes vans to transport you to the hotel.
Our representative will quickly review your schedule for the coming days for your peace of mind. Renue makes it worry-free, so don't worry!
Evening
You traveled all this way, so would you like to check our list of recommended restaurants? We can make reservations for you to enjoy the great food and warm atmosphere of Puerto Vallarta.
Check out the Renue chauffeur for recommendations, reservations, leisure activities, and your transportation needs.
A better life starts now!
Day 1. Enjoy The Renue Difference.
Count on your Renue Advisor and staff to help you have a pleasant experience. Our Renue chauffeur will pick you up from the hotel and take you to The Renue Medical Centre in the Joya Hospital. Our staff will welcome and assist you at the Centre.
Our staff will check you in at the Centre and take you on a tour of the facilities, including The Renue Laboratory, where your stem cells and exosomes are produced. You will also visit the Hyperbaric Chamber facility, an essential part of The Renue Difference.
After your check-in, our medical associates will proceed with any necessary blood work or tests organized by your Patient Advisor.
After that, you will meet with your doctor to review your file. Then, your doctor will make any adjustments to your treatment schedule submitted by your Renue Patient Advisor.
Once your doctor has reviewed your file, additional testing might be required—for example, X-Rays, MRIs, and others.
After that, you will have your first Hyperbaric Oxygen Therapy (HBOT) session.
Following your first treatment session, our Renue chauffeur will return you to your hotel.
Evening
Do you have any plans for the evening? Or maybe you would need a chauffeur?
Remember that relaxation can improve your health, too. Ask our Renue chauffeur for suggestions. They know the places to go in Puerto Vallarta.
Treatment Day & Second Hyperbaric Session
Day 2. Now you're a pro!
Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Centre.
The medical team will welcome you and start your treatment for Hashimoto’s Thyroiditis as soon as you arrive:
300 Million Stem Cells IV*
16 Billion Exosomes*
*The actual quantity of Stem Cells depends on the patient’s body weight and severity of the disease.
Then, after your treatment and second Hyperbaric Chamber session, the Renue chauffeur will return you to the hotel.
Evening
Puerto Vallarta is a beautiful place; we suggest you don't miss out and enjoy your stay. You know it: ask our Renue chauffeur for suggestions and have fun!
The third and fourth Hyperbaric Session makes a difference.
Day 3 & 4. You're almost done.
Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Centre.
Your scheduled treatment will start as soon as you arrive.
Then, after your treatment and second Hyperbaric Chamber session, the Renue chauffeur will return you to the hotel.
Evening
Your Renue Journey allows you to explore all that Puerto Vallarta has to offer.
Ask our Renue chauffeur for suggestions, and remember to enjoy yourself.
It's not over yet.
Day 5. Departure or extended stay?
Our Renue chauffeur will pick you up from the hotel. Then, they will take you to the airport or another treatment according to your schedule.
However, maybe you would like to extend your stay and your wellness holiday because Puerto Vallarta is stunning!
Talk to our Renue chauffeur. Our team will contact you to confirm all details: tours, restaurants, and other treatments you would like to have.
Are you going to miss us?
Don't forget our follow-up treatments. Talk to your Patient Advisor:
30, 60 & 90 days follow-up: HT symptoms clinical evaluation, flare-up frequency, and lab test results
Six months post-treatment: HT symptoms clinical evaluation, flare-up frequency, lab test results, X-ray report, and review of the diagnostic criteria from the American College of Rheumatology
Significance of Hyperbaric Chambers post-treatment:
Three sessions of Hyperbaric Chambers are given to the patients after the treatment to:
Support the immune system by reducing toxicity and inflammation of the affected regions by using concentrated oxygen therapy
Kill the harmful organisms and bacteria, fungi, and viruses that may contribute to autoimmunity and associated detrimental effects of their disease in an individual
Mobilize the Stem Cells recently administered inside the body
Balance the immune system, increase the levels of body energy, and enhance brain functioning
Reduce the events of swelling, bad sleeping routine, and discomfort
Enhance the growth factors induced by the limbic cells
EXPECTED RESULTS
SCT to live a better life: Benefits and outcomes
The effectiveness of Stem Cell Treatment can improve all your symptoms, causing a considerable impact on your quality of life and daily activities.
As part of The Renue Difference, you will receive three Hyperbaric Chamber sessions that greatly improve SCT efficacy and stimulate the body cells to combat Hashimoto's Thyroiditis (HT). These sessions comprise four days: one day before treatment, two after treatment, and on the day of treatment.
Expected results and prognosis:
Expected result 1: Immediate control of associated symptoms of the HT post-treatment, but require monitoring of risk factors for Hashimoto Thyroiditis.
Expected result 2: More independence in ADLs and IADLS, mobility, and reduction in muscle stiffness, and feeling of physical activeness after six months of injection.
Expected result 3: Increased independence, weight management, decreased damage progression, improved balance and coordination, hair regrowth, and more life satisfaction.
FREQUENT QUESTIONS
What are the risk factors of Stem Cell Therapy for HT?
Generally, Stem Cell Therapy has a satisfactory safety profile, good prognosis, and effectiveness.
However, no medical procedure is 100% safe; so, the most frequent or common risk factors of SCT can be:
Lethargy and fatigue
Bleeding from the site of injection
Fever
Painful injection site
Allergic reactions
Management of Risks
Fever, lethargy, and pain are managed through the appropriate drugs along with the treatment. Bleeding and swelling of the injured site are manageable via proper technique. Allergic reactions are preventable through pre-injection history and care.
The benefits and effects of Stem Cell Therapy depend on several factors: the patient's health condition, underlying issues, lifestyle, and others. To assess your expected results, we would like to know more about you. A medical advisor will talk to you about your diagnosis and treatment options and collect information for the attending physician; they can answer all your initial questions:
Will the therapy work for my case?
What does the treatment involve? Is it painful?
Is it expensive? How much does it cost?
Start your Wellness Journey!
Click on the button below to book a consultation to answer your questions and discuss your medical history, your treatment journey, and your goals.