Stem Cell Therapy for Parkinson's Disease

Parkinson's Disease (PD) is a chronic neurological disorder caused by the loss of dopaminergic neurons in the brain. This progressive disease affects movement and coordination, with symptoms starting slowly and worsening over time.

Dopamine Depletion: Abnormalities in dopamine disrupt normal brain activity, leading to impaired movements and tremors.

Environmental Factors: Exposure to toxins and chemicals can increase the risk.

Lewy Bodies: Protein aggregates, particularly alpha-synuclein, interfere with brain function.

Genetic Predisposition: Certain genetic mutations can increase the risk, though genetic transmission is less common.

Parkinson's Disease (PD) is characterized by distinctive features that set it apart from other conditions. While initial signs and symptoms may be subtle, they become more pronounced over time. The primary symptoms of PD are often remembered by the acronym TRAP:

1. Tremors:

• Tremors involve involuntary, repetitive shaking or movement of the hands, fingers, and limbs, often observed even at rest. The most common type is the pill-rolling tremor.

2. Rigidity:

• Muscle stiffness is a hallmark of Parkinson's Disease. It can affect any part of the body and limit movement.

3. Akinesia (Bradykinesia):

• This refers to the slowness of movement. Patients may experience a reduced walking speed and have difficulty initiating and stopping movement. The festinating gait, characterized by short, rapid steps, is a key feature. Patients often need external cues to start or stop walking and may struggle to rise from a seated position.

4. Postural Imbalance:

• Many patients exhibit a stooped posture, which alters their center of gravity and increases the risk of falls.

Additional Symptoms

• Micrographia:
• Writing may become small and difficult to read.
• Speech Changes:
• Alterations in speech patterns, such as reduced volume or monotone speech, may occur.

These symptoms collectively help in diagnosing Parkinson's Disease and differentiating it from other conditions.

Medications commonly used to manage Parkinson's disease include:

Inhaled carbidopa-levodopa

Carbidopa-levodopa (oral and infusion)

Dopamine agonists

Catechol-O-methyltransferase (COMT) inhibitors

MAO B inhibitors

Anticholinergics

Amantadine

Medication, exercise, and rehabilitation programs are also essential components of treatment.

Stem cell therapy (SCT) focuses on replacing damaged dopaminergic neurons in the brain. This innovative approach has the potential to be more effective and less risky than traditional methods. Though still in the developmental stage, rapid advancements highlight its potential.

Monitoring disease patterns

Repairing nerve cells

Developing new neurons

Replacing damaged cells

Induced pluripotent stem cells (iPS) can significantly regenerate brain cells. SCT involves inserting these stem cells into the putamen, the brain area controlling movement.

Stem cells, which can differentiate into specialized cells, are classified into adult and embryonic stem cells. In Parkinson's disease, SCT aims to replace damaged brain cells with healthy dopamine cells derived from stem cells, including mesenchymal cells and umbilical cord cells.

Exosomes, when used with stem cell therapy, show promise in treating neurological disorders like stroke, Parkinson's disease, and Alzheimer's disease. Research indicates that exosomes enhance:

• Angiogenesis
• Neurogenesis in ischemic boundary zones
• Neurite remodeling
• Synaptic plasticity

Combining stem cell therapy with exosomes can improve function, tissue recovery, and cellular regeneration in individuals with neurological diseases. Benefits of Exosomal Therapy Post-Stroke:

Oligodendrogenesis: Formation of new oligodendrocytes

Remyelination: Restoration of the myelin sheath

Axonal Sprouting: Growth of new axons

Exosomes also boost the expression of neuroprotective microRNAs (miR-133b, miR-210, miR-184, miR-17-92), contributing to a positive prognosis.

Parkinson's disease remains a challenging condition, but advancements in stem cell and exosomal therapies offer hope for improved treatments and outcomes.

SCT to live a better life: Benefits and outcomes

The effectiveness of Stem Cell Treatment can improve all your symptoms, causing a considerable impact on your quality of life and daily activities.

As part of The Renue Difference, you will receive three Hyperbaric Chamber sessions that greatly improve SCT efficacy and stimulate the body cells to combat Parkinson's Disease (PD). These sessions comprise three days: one day before treatment, after treatment, and on the day of treatment.

Expected result 1: Immediate control of involuntary or uncontrolled upper and lower limb movements

Expected result 2: More independence in ADLs and IADLS, mobility, coordination, and gait after six months of injection

Expected result 3: Increased independence, decreased neuro damage progression, reduced memory decline, balance, stable posture, and more life satisfaction

After the SCT procedure, an MRI test depicts the further need for the treatment at a specific body site.

Talk to our Patient Advisor to learn more about SCT at The Renue Centre.

Stem Cell Therapy has a good prognosis with little to no side effects of the therapy.

The most frequent or common risk factors of SCT can be:

Fever

Exaggeration of uncontrolled movements

Painful injection area /site

Lethargy and fatigue

Allergic reactions

Allergic reactions are preventable through pre-injection history and care. Fatigue, fever, and pain are managed through the appropriate drugs along with the treatment.

The benefits and effects of Stem Cell Therapy depend on several factors: the patient's health condition, underlying issues, lifestyle, and others. To assess your expected results, we would like to know more about you. A medical advisor will talk to you about your diagnosis and treatment options and collect information for the attending physician; they can answer all your initial questions:

Will the therapy work for my case?

What does the treatment involve? Is it painful?

Is it expensive? How much does it cost?