Stem Cell Therapy for Type 2 Diabetes

Type 2 diabetes is a chronic disease that impairs the body's ability to use insulin effectively, leading to high levels of sugar in the blood. This condition, known as insulin resistance, prevents the body from converting glucose into energy, causing it to accumulate in the blood and cells.

Type 2 diabetes is the most common form of diabetes in the United States, affecting over 29 million people. Additionally, more than 85 million people are in the pre-diabetic stage and at risk of developing diabetes within a few years.

In type 2 diabetes, the body fails to use insulin properly, leading to an increase in glucose levels in the blood. Initially, the pancreas produces more insulin to counteract this, but over time, it cannot keep up, resulting in high blood sugar levels.

Genetics: Family history and genetic predisposition affect the insulin-producing glands.

Obesity: Excess fat, especially in the abdominal area, can cause insulin resistance.

Metabolic Syndrome: Conditions like high blood pressure, high triglycerides, high cholesterol, and high blood sugar increase the risk.

Cellular Communication Issues: Defects in cell signaling can lead to improper glucose regulation.

Pancreatic Beta Cell Damage: Damage to insulin-producing beta cells impairs insulin production, leading to high blood sugar levels.

Symptoms of type 2 diabetes can range from mild to severe and may include:

• Extreme thirst
• Blurred vision
• Frequent urination, especially at night
• Numbness or tingling in hands, fingers, feet, or limbs
• Fatigue
• Slow-healing wounds
• Constant hunger
• Increased susceptibility to yeast and microbial infections
• Rashes, especially in the genital area
• Acne in unusual places
• Unexplained weight loss
• Pear-shaped body with more fat around the midsection

Treatment for type 2 diabetes involves three main steps:

1. Medications: Various medications are used to manage blood sugar levels, including sulfonylureas, meglitinides, biguanides, DPP-4 inhibitors, TZDs, alpha-glucosidase inhibitors, bile acid sequestrants, SGLT2 inhibitors, dopamine receptor agonists, GLP-1 receptor agonists, and pramlintide.

2. Diet and Lifestyle Changes: Adopting a healthy diet and making lifestyle changes are crucial in managing diabetes.

3. Physical Activity: Regular exercise helps improve insulin sensitivity and overall health.

Insulin Therapy

Insulin therapy involves injecting insulin to regulate blood sugar levels. Injections can be administered in the abdomen, upper arm, buttocks, or thighs. Insulin therapy is often temporary but may be necessary to manage blood sugar levels effectively.

Stem cell therapy is an emerging treatment option that offers innovative solutions for managing type 2 diabetes. Stem cells can regenerate neural cells, somatic cells, cartilage, and endocrine cells, including insulin-producing beta cells in the pancreas.

Importance of Stem Cell Therapy

Stem cell therapy involves using the patient's isolated stem cells from their bone marrow to revitalize organ and cell function. Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) from bone marrow can improve chronic inflammatory and autoimmune conditions.

How Stem Cells Work:

HSCs: These cells include white blood cells (monocytes) and red blood cells, which help improve inflammatory and autoimmune conditions.

MSCs: These cells enter the bloodstream during injury and target inflammation, acting as immunomodulatory and protective agents. MSCs can replace defective beta cells, replenishing the body's insulin needs.

Stem Cell Therapy provides an approach to treatment to utilize the isolated Stem Cells of the patients from their bone marrow. Stem Cell Therapy has multiple benefits for the patients to revitalize the functioning of the human organs and cells.

HSC (Hematopoietic Stem Cells) is the major source of cells in humans' circulating and peripheral blood in the bone marrow. Hematopoietic Stem Cells include white blood cells (monocytes) and red blood cells. According to the research studies, bone marrow-derived white blood cells (monocytes) can help in improving chronic inflammatory and other infectious auto-immune diseases or conditions.

Other than the HSCs, MSCs (Mesenchymal Stem Cells) are also present inside the bone marrow of an individual. Researchers claim that MSCs can effectively enter the circulating bloodstream during the injury event. After entering the injury site, these cells act as a home to the inflammation of injured tissues in the body.

Once the MSCs enter the injured site, they act as an immunomodulatory and protective agent for the autoimmune conditions. Moreover, these stem cells can replace the defective beta cells of the pancreas to replenish the need for body insulin.

Exosomes, combined with MSCs, help regulate inflammatory cytokines, the microenvironment, and immune cells in autoimmune diseases. They influence both adaptive and innate immune cells, including macrophages, Treg cells, Th17, and CD4+Th1 cells.

Benefits of Exosome-Combined MSCs:

• Regulate T-cell subsets in autoimmune diseases
• Reduce pro-inflammatory cytokines (Th17, TH1)
• Increase anti-inflammatory Treg concentration
• Improve conditions like rheumatoid arthritis (RA) and graft-versus-host disease (GVHD)
• Promote M1-M2 macrophage conversion, reducing pro-inflammatory effects and facilitating metabolic homeostasis

This advanced therapy offers a comprehensive approach to managing type 2 diabetes and related autoimmune conditions, providing hope for improved patient outcomes and quality of life.

The Stem Cell Therapy (SCT) at The Renue Centre is a holistic approach to treating Diabetes Type 2. Your Renue Journey does not end after your last day of SCT. We follow up with you to assert your progress, following four phases:

Pre-treatment: Clinical evaluation, lab test results, and other diagnostic procedures.

You will take our Renue Epigenetic Test powered by TruDiagnostics that will assert your biological age and other important health markers. Your TruDiagnostics test is part of The Renue Difference. It provides your doctor with critical information about your health and your true age (biological vs. chronological). After the epigenetic test and we have received all your medical records, your Patient Advisor will assist you in planning your travel to Puerto Vallarta.

Treatment day: First of all, blood is drawn from the bone marrow through the aspiration procedure. Secondly, the sample is activated to augment the efficiency. After activating the cells, they are administered inside the body intravenously and through direct site injections. The dosage of the Stem Cells depends upon the customized need of the particular disease.

30, 60 & 90 days after the treatment: To check for flare-up frequency, improvements, and other symptoms

Six months after treatment: Lab tests, flare-up frequency, clinical evaluation, and disease prognosis

SCT to live a better life: Benefits and outcomes

The effectiveness of Stem Cell Treatment can improve all your symptoms, causing a considerable impact on your quality of life and daily activities.

As part of The Renue Difference, you will receive three Hyperbaric Chamber sessions that greatly improve SCT efficacy and stimulate the body cells to combat Diabetes Type 2. These sessions comprise three days: one day before treatment, after treatment, and on the day of treatment.

According to results, clinical outcomes, and pre and post-treatment observations, SCT has been shown to help

reduce Diabetes Type 2 progression

speed up tissue repair

regrow and repair tissues after six months

After the SCT procedure, an MRI test depicts the further need for the treatment at a specific body site.

Talk to our Patient Advisor to learn more about SCT at The Renue Centre.

Expected results and prognosis:

Expected result 1: Immediate stabilization of the blood sugar levels, poor wound healing, frequent urination, and fatigue

Expected result 2: More independence in ADLs and IADLs

Expected result 3: Increased independence, decreased neuropathy symptoms, improvement in co-morbidities of the patient

The Stem Cell Therapy risks are low and infrequent because of the therapy's high safety domain.

You can expect the most frequent side-effect of Stem Cell Therapy as follows:

Allergic reactions

Muscle soreness

Fever

Painful injection area /site

Lethargy and fatigue

Allergic reactions are preventable through pre-injection history and care. Fatigue, fever, and pain are managed through the appropriate drugs along with the treatment.

All the treatment options for Diabetes Type 2 have been temporary options for just treating the symptoms. With the innovative Stem Cell Therapy approach, the quality of life has significantly improved in the patients. SCT has the potential to be more effective than previous methods and also carries less risk. In recent times, Stem Cell Therapy is still in its initial phase, which requires compound research and discoveries for further improvements.