Stem Cell Therapy for Alzheimer's Disease

Alzheimer's Disease (AD) is a neurological disorder characterized by brain atrophy, resulting in the progressive loss of brain cells. It is the most common cause of dementia, leading to a decline in cognitive abilities, social skills, and behavioral functions, ultimately impairing a patient's ability to live independently.

In the United States, approximately 5.8 million individuals aged 65 and older have Alzheimer's Disease. The incidence rate increases to 80% in those over 75. In advanced stages, complications such as infections, malnutrition, and dehydration can significantly impair brain functions and may lead to death.

Early symptoms include difficulty recalling recent conversations or events, progressing to severe memory impairments and inability to perform daily tasks.

Alzheimer's Disease is influenced by genetic, environmental, and lifestyle factors. Two key proteins play a critical role in its pathology:

Tau Protein: Normally supports the internal transport system of neurons. In AD, tau proteins change structure and form neurofibrillary tangles, disrupting the cellular transport system and becoming toxic.

Beta-Amyloid Proteins: Larger protein fragments that form toxic clusters, disrupting cell-to-cell communication and forming amyloid deposits, which include cellular debris.

Genetics and Family History: First-degree relatives have a higher risk, particularly those with the APOE e4 allele.

Age and Gender: Risk increases with age, and women are at greater risk due to longer life expectancy.

Down Syndrome: Individuals with Down syndrome have an increased accumulation of beta-amyloid protein, leading to an earlier onset of AD.

Traumatic Head Injuries: A history of traumatic brain injury (TBI) increases the risk, with the highest risk occurring within the first six months to two years post-injury.

Memory Loss: Progressive and more severe than normal age-related decline.

Repeatedly asking the same questions.

Forgetting important events, appointments, and conversations.

Misplacing items and getting lost in familiar places.

Difficulty remembering family members' names.

Apathy and depression

Social withdrawal and isolation

Mood swings and distrust

Aggressiveness and irritability

Altered sleep patterns and wandering

Impaired judgment and problem-solving skills

Difficulty multitasking and concentrating

Treatment Journey for Alzheimer's Disease.

AD treatments include two main types of drugs:

Namenda (Memantine): Helps slow disease progression and improve brain cell communication.

Cholinesterase Inhibitors: Improve brain cell communication by preventing the depletion of chemical messengers. Examples include Exelon (rivastigmine), Razadyne (galantamine), and Aricept (donepezil).

Stem Cell Therapy (SCT) offers hope for more effective treatments. Stem cells, which can differentiate into various cell types, are derived from embryos, neural tissue, or induced pluripotent cells.

Stem Cell Sources:

1. Embryonic Stem Cells (ESCs): Derived from blastocysts, capable of becoming any cell type. ESC therapy can help AD patients by facilitating memory and learning.

2. Mesenchymal Stem Cells (MSCs): Found in bone marrow, fat, umbilical cord, and stem cell pupae. MSCs are often derived from umbilical cord blood and help develop other tissues.

• Benefits include reducing beta-amyloid plaques, hyperphosphorylation of tau proteins, reversing microglial inflammation, and promoting anti-inflammatory cytokines.

3. Neural Stem Cells: Located in the brain, particularly in the hippocampus and subventricular areas, capable of generating other brain cells.

Exosomes, when used with stem cell therapy, show promise for treating neurological disorders such as stroke, Parkinson's disease, and Alzheimer's disease. They enhance:

Angiogenesis: Improved blood flow

Neurogenesis: Growth of new brain cells

Neurite Remodeling and Synaptic Plasticity: Repairing and enhancing neural connections

Post-Stroke Benefits of Exosomal Therapy:

Oligodendrogenesis: Formation of new oligodendrocytes

Remyelination: Restoration of the myelin sheath

Axonal Sprouting: Growth of new axons

Exosomes also boost the expression of neuroprotective microRNAs (miR-133b, miR-210, miR-184, miR-17-92), aiding in disease prognosis.

These innovative treatments offer a comprehensive approach to managing Alzheimer's Disease, providing hope for improved patient outcomes and quality of life.

The Stem Cell Therapy (SCT) at The Renue Centre is a holistic approach to treating Alzheimer's Disease.

Your Renue Journey does not end after your last day of SCT. We follow up with you to assert your progress, following four phases:

The treatment of Alzheimer's Disease with Stem Cells consists of four phases:

Pre-treatment: Clinical evaluation, lab test results, and other diagnostic procedures. You will take our Renue Epigenetic Test powered by TruDiagnostics that will assert your biological age and other important health markers. Your TruDiagnostics test is part of The Renue Difference. It provides your doctor with critical information about your health and your true age (biological vs. chronological).

After the epigenetic test and we have received all your medical records, your Patient Advisor will assist you in planning your travel to Puerto Vallarta.

Treatment day: The treatment starts with taking a specific amount of blood through apheresis. After taking the Stem Cells, the rest of the blood is returned to the donor.

30, 60 & 90 days post-treatment follow-up: AD symptoms clinical evaluation, flare-up frequency, and lab test results.

Six months post-treatment: AD symptoms clinical evaluation, flare-up frequency, lab test results, X-ray report, and review of the diagnostic criteria from the American College of Rheumatology.

SCT to live a better life: Benefits and outcomes

The effectiveness of Stem Cell Treatment can improve all your symptoms, causing a considerable impact on your quality of life and daily activities.

As part of The Renue Difference, you will receive three Hyperbaric Chamber sessions that greatly improve SCT efficacy and stimulate the body cells to combat Alzheimer's Disease. These sessions comprise three days: one day before treatment, after treatment, and on the day of treatment.

According to results, clinical outcomes, and pre and post-treatment observations, SCT has been shown to help

Reduce Alzheimer progression

Speed up tissue repair

Regrow and repair tissues after six months

After the SCT procedure, an MRI test depicts the further need for the treatment at a specific body site.

Talk to our Patient Advisor to learn more about SCT at The Renue Centre.

Expected results and prognosis:

Expected result 1: Slower memory decline after three months after treatment.

Expected result 2: More independence in ADLs and IADLS after six months of injection.

Expected result 3: Increased independence, reduced memory decline, more life satisfaction.

The Stem Cell Therapy risks are low and infrequent because of the therapy's high safety domain.

The most expected or common risk factors of SCT can be:

Painful injection area /site

Lethargy and fatigue

Allergic reactions

Fever

Allergic reactions are preventable through pre-injection history and care. Fatigue, fever, and pain are managed through the appropriate drugs along with the treatment.

Stem Cell Therapy is a new and promising method of treating Alzheimer's Disease. It has the potential to be more effective than previous methods and also carries less risk. At present, Stem Cell Technology is still in the developmental stage, but rapid developments and advances indicate its potential uses in direct treatments of Alzheimer's Disease.

The benefits and effects of Stem Cell Therapy depend on several factors: the patient's health condition, underlying issues, lifestyle, and others. To assess your expected results, we would like to know more about you. A medical advisor will talk to you about your diagnosis and treatment options and collect information for the attending physician; they can answer all your initial questions:

Will the therapy work for my case?

What does the treatment involve? Is it painful?

Is it expensive? How much does it cost?